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University of Connecticut Health Center - Know Better Care The Gregory P. Mullen NMR Structural Biology Facility & Biophysical Core Facility

Nuclear Magnetic Resonance (NMR) Facility

The NMR Facility provides a state-of-the-art environment for studying the structure, dynamics, folding, and interactions of biological macromolecules. The primary goal of the facility is the application of advanced NMR techniques to important and challenging biomedical problems. To meet these challenges, facility staff develop new methods to enhance and facilitate bio-molecular applications of NMR. In addition to providing access to state-of-the-art instrumentation for experienced users, the facility provides support for new users interested in bio-molecular applications of NMR.

Biophysical Core Facility & Protein Production Services

The biophysical core facility provides state-of-the-art instruments for protein characterization including circular dichroism (CD) for monitoring secondary structure and protein stability, surface plasmon resonance (SPR) for measuring the kinetics of biomolecule interactions, isothermal titration calorimetry (ITC) for measuring the thermodynamics of biomolecule interactions, and fluorescence spectroscopy for probing proteins under different conditions and monitoring ligand interactions. The core also maintains fermentation equipment and a robot used in cell free protein expression and provides custom protein production and purification for both unlabelled and labelled proteins suitable for structural studies or biological assays.

Contact Us

The Gregory P. Mullen
NMR Structural Biology Facility & Biophysical Core Facility
UConn Health Center

LSB028 (NMR)
L-2044 (Biophysical Core)
263 Farmington Avenue Farmington, CT 06030

Jeffery C. Hoch, Ph.D.
Facility Director
Email: hoch@uchc.edu

Mark W. Maciejewski, Ph.D.
Facility Manager
Phone: 860-679-1943
Email: markm@uchc.edu


Samples from outside users should be shipped to:

Mark Maciejewski
UConn Health Center
263 Farmington Avenue
Room L-5001
Farmington, CT 06030-3305